A Double‐Blind Comparison of Clonazepam and Placebo in the Treatment of Neuroleptic‐Induced Akathisia
作者:
D. Pujalte,
T. Bottaï,
B. Huë,
R. Alric,
R. Pouget,
J. Blayac,
P. Petit,
期刊:
Clinical Neuropharmacology
(OVID Available online 1994)
卷期:
Volume 17,
issue 3
页码: 236-242
ISSN:0362-5664
年代: 1994
出版商: OVID
关键词: Clonazepam;Akathisia
数据来源: OVID
摘要:
The present study was designed to investigate the efficacy of clonazepam in neuroleptic-induced akathisia. Twelve patients were treated during 2 weeks with clonazepam or placebo in a double-blind randomized design. Akathisia was scored by an independent rater before and after treatment, as well as 1 week after medication withdrawal. Clonazepam (0.5–2.5 mg/day) induced a significantly higher reduction in the akathisia scores than placebo (p < 0.05). One week after stopping the drug, there was a partial but significant relapse in the treated group as compared with controls, in whom the symptoms remained stable. In addition, the clinical improvement was significantly correlated with the daily dose of clonazepam (rs= 0.827; p < 0.002). These results support the potential usefulness of clonazepam in the treatment of neurolepticinduced akathisia and suggest an optimal daily dose in the range of 10–40 μg/kg.
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