Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist
作者:
Priscilla Chan,
Savio Chan,
Wing-ho Yung,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 4
页码: 671-675
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cannabinoid;GABA;IPSC;Substantia nigra
数据来源: OVID
摘要:
WHOLE-CELL patch-clamp recordings were made from substantia nigra pars reticulata (SNR) neurones in rat midbrain slices to investigate the electrophysiological effects of cannabinoids. The cannabinoid receptor agonist WIN 55212-2 (10 μM) significantly reduced intranigrally evoked and spontaneous inhibitory post- synaptic currents (IPSCs) which were mediated by GABAAreceptors. The postsynaptic current induced by bath application of GABA was not affected by the presence of WIN 55212-2. The actions of WIN 55212-2 were not mimicked by the inactive enantiomer WIN 55212-3. WIN 55212-2 also hyperpolarized the membrane of SNR neurones in a tetrodotoxin/0–Ca2+-insensitive manner. These data suggest that cannabinoids modulate the activity of SNR neurones by presynaptic inhibition of GABA inputs. They may also exert a direct post-synaptic inhibition on these neurones.
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