Sequence Comparison and Predicted Structure for the Four Exon-Encoded Regions of Human Insulin-Like Growth Factor Binding Protein 4
作者:
LandaleEdwin C.,
StrongDonna D.,
MohanSubburaman,
BaylinkDavid J.,
期刊:
Growth Factors
(Taylor Available online 1995)
卷期:
Volume 12,
issue 4
页码: 245-250
ISSN:0897-7194
年代: 1995
DOI:10.3109/08977199509028963
出版商: Taylor&Francis
关键词: IGFBP;gene structure;exons;protein structure prediction
数据来源: Taylor
摘要:
AbstractThe IGFBPs bind to and modulate the function of the IGFs in various ways. Human IGFBP-4 inhibits IGF mediated cell proliferation. The IGFBP exon-encoded regions were aligned and secondary structure predictions for hIGFBP-4 were developed yielding predicted 3D co-ordinates for each such region of hIGFBP-4. The exon 1 encoded region is the most conserved among the IGFBPs. That of hIGFBP-4 is predicted as an array ofβ-strands that include the glycine and cysteine rich IGFBP concensus pattern and that terminate with a helix. The exon 2 encoded region is the most variable among the IGFBPs. That of hIGFBP-4 is predicted as mostly an amphipathic helix. The remaining regions are also conserved among the IGFBPs. Those of hIGFBP-4 are also predicted to contain helices. The predicted structure of hIGFBP-4 comprises amino terminalβ-strands with four helices in the carboxy terminal two thirds of the molecule.
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