Summary:: Neural regulation of pituitary function can serve as a basis for understanding endocrine and reproduction dysfunction in epilepsy. Because the pituitary gland is the final common pathway for central neural modulation of the endocrine system, hypothalamic control of pituitary function is important. The syndrome of functional hypothalamic amenorrhea is an example of stress‐induced alteration in endocrine function and may serve as a model to suggest the impact of limbic system activation on reproduction and the endocrine milie