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Application of Difference and Derivative Ultraviolet Spectrometry for the Assay of Some Benzodiazepines

 

作者: MohamedE. Abdel-hamid,   MagdiM. Abdel-khalek,   MohamedS. Mahrous,  

 

期刊: Analytical Letters  （Taylor Available online 1984）
卷期: Volume 17, issue 12  

页码: 1353-1371

 

ISSN:0003-2719

 

年代: 1984

 

DOI:10.1080/00032718408065313

 

出版商: Taylor & Francis Group

 

关键词: clonazepam;diazepam;medazepam;differential spectrophotometry;second derivative;differential second derivative

 

数据来源: Taylor

 

摘要:

Differential (δ A), second derivative (D2) and differential second derivative (δ D2) ultraviolet spectrophotometric methods have been described for the quantitiative estimation of clonazepam, diazepam and medazepam in pharmaceutical formulations such as drops, tablets and capsules. Interferences due to excipients and diluents are thereby avoided. Accuracy of the analyses with the proposed procedures is significantly greater than the conventional spectrophotometric and official methods.

 

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