Splenectomy after angiographic embolization of the splenic artery in patients with massive splenomegaly and severe thrombocytopenia, in juvenile subacute myelomonocytic leukemia
作者:
Peter G. Steinherz,
Philip R. Exelby,
Jean Young,
Robin C. Watson,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1984)
卷期:
Volume 12,
issue 1
页码: 28-32
ISSN:0098-1532
年代: 1984
DOI:10.1002/mpo.2950120108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: chronic myelogenous leukemia;juvenile subacute myelomonocytic leukemia;splenectomy;splenic embolization;thrombocytopenia
数据来源: WILEY
摘要:
AbstractSplenectomy for massive splenomegaly in thrombocytopenic patients refractory to platelet transfusions carries increased surgical risks. Blocking of the splenic artery may reduce the size of the organ, prolong the survival of transfused platelets, and reduce the surgical complications. We describe four cases of extreme splenomegaly and thrombocytopenia where successful splenectomy was carried out after angiographic embolization of the splenic artery in children with ju venile chronic myelogenous leukemia. Significant improvement was observed in platelet counts and in the survival of platelets after transfusions in three of the patients. There was a concomitant decrease in transfusion requirements. Isoimmunization prevented prolonged platelet survival in the fourth case. We recommend earlier splenectomy in these patients to reduce transfusion requirements and delay the onset of poor platelet survival after transfusions.
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