A stability indicating high performance liquid chromatography method has been developed for simultaneous determination of acetaminophen, salicylamide and phenyltoloxamine. The reversed-phase method utilizes UV detection at 220 nm and a C8 column. This paper presents the data to support linearity, precision, specificity, and robustness of the method. The known potential degradation products of acetaminophen, p-aminophenol, p-nitrophenol, precursor impurity p-hydroxyacetophenone, the potential degradation product of salicylamide, salicylic acid, and precursor impurity ethylsalicylate were separated for quantitation simultaneous with parent compounds. Quantification was achieved by peak area and external standard method. This method can be employed in determining stability, assay, content uniformity, and dissolution of the combination in pharmaceutical dosage forms.