Epicardial Outgrowth Inhibition Leads to Compensatory Mesothelial Outflow Tract Collar and Abnormal Cardiac Septation and Coronary Formation
作者:
Adriana Gittenberger-de Groot,
Mark-Paul Vrancken Peeters,
Maarten Bergwerff,
Monica Mentink,
Robert Poelmann,
期刊:
Circulation Research: Journal of the American Heart Association
(OVID Available online 2000)
卷期:
Volume 87,
issue 11
页码: 969-971
ISSN:0009-7330
年代: 2000
出版商: OVID
关键词: epicardium;coronary vasculature;myocardial differentiation;ablation;chimerization
数据来源: OVID
摘要:
In the present study, we investigated the modulatory role of the epicardium in myocardial and coronary development. Epicardial cell tracing experiments have shown that epicardium-derived cells are the source of interstitial myocardial fibroblasts, cushion mesenchyme, and smooth muscle cells. Epicardial outgrowth inhibition studies show abnormalities of the compact myocardial layer, myocardialization of cushion tissue, looping, septation, and coronary vascular formation. Lack of epicardial spreading is partly compensated by mesothelial outgrowth over the conotruncal region. Heterospecific epicardial transplant is able to partially rescue the myocardial development, as well as septation and coronary formation.
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