Clinical Significance ofbcr-ablGene Rearrangement Detected by the Polymerase Chain Reaction After Allogeneic Bone Marrow Transplantation in Chronic Myelogenous Leukemia
作者:
PichertGabriella,
RitzJerome,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 10,
issue 1-2
页码: 1-8
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309147350
出版商: Taylor&Francis
关键词: bcr-abl;gene rearrangement;PCR;allogeneic bone marrow transplantation;CML;chronic myelogenous leukemia
数据来源: Taylor
摘要:
Although serial detection of bcr-abl positive cells by PCR appears able to identify distinct patient groups with different risks of relapse following BMT, there remain many unanswered questions regarding the clinical utility and biological significance of PCR detectable cells in this disease. Many of the studies summarized have conflicting results and the influence of various clinical parameters which are known to affect the risk of relapse post-BMT has not yet been consistently associated with the ability to detect bcr-abl positive cells by PCR. These clinical parameters include GVHD, T-cell depletion and intensity of immunosuppression following BMT. Prospective studies with larger patient numbers will be necessary to define the impact of these factors in PCR status and relapse. The answers to all these questions will increase our understanding of the biology of chronic myelogenous leukemia and help provide more effective therapies for the future.
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