A study was conducted to identify and compare the effect produced on oral mucosa by the application of oral hygiene by the use of either a toothette or a toothbrush at two-, three-, or four-hour intervals during an eight-hour period for ten days. The sample consisted of 48 geriatric patients randomly selected from an extended care facility. Two investigators were responsible for scoring nine dependent variables—salivation, tongue moisture, tongue color, moisture of palates, color of gingiva, condition of membranes, lip texture, lip moisture, and soft tooth debris-twice daily. Data were analyzed using multiple regression analysis. Results of the study indicated significant improvement in six dependent variables in the four-hour interval groups. In the two-hour interval groups, two dependent variables were improved significantly. The toothbrush was more effective in stimulating gingival tissue and removing soft tooth debris; the toothette was found to be more effective in producing improvement in other oral tissues.