Trifluoroethanol has been postulated to be an intermediate in the formation of trifluoroacetate during the biotransformation of halothane. As much as 80 per cent of injected C-labeled trifluoroethanol could be recovered as trifluoroacetate in the urine of two volunteers. Excretion of radioactivity lasted seven to nine days after administration of trifluoroethanol. It is unlikely that trifluoroethanol is an endproduct of halothane metabolism in man.