CYTOKINE PRODUCTION BY C57BL/6 MOUSE SPLEEN CELLS IS SELECTIVELY REDUCED BY EXPOSURE TO PROPANIL
作者:
Wei Zhao Rosana Schafer John B. Barnett,
期刊:
Journal of Toxicology and Environmental Health, Part A
(Taylor Available online 1998)
卷期:
Volume 55,
issue 2
页码: 107-120
ISSN:1528-7394
年代: 1998
DOI:10.1080/009841098158548
出版商: Informa UK Ltd
数据来源: Taylor
摘要:
Numerous immunomodulatory effects are caused by propanil, an extensively used postemergent herbicide. The T-dependent antibody response is suppressed after exposure to propanil, raising the question of propanil's effect on T-helper-cell populations. In the present study, we show that the production of several T-cell cytokines is affected by propanil after in vivo or in vitro exposure. In vivo exposure to propanil caused the reduction of interleukin (IL)-2, IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon (IFN)- production in concanavalin A-stimulated spleen cell cultures established 2 d after exposure. IFN- and GM-CSF production had recovered by d 4 postexposure; however, IL-2 and IL-6 levels continued to be depressed through d7 postexposure. Continuous in vitro treatment of normal spleen cells with propanil decreased IL-2, IL-6, GM-CSF, and IFN- production after concanavalin A activation. Pulsing normal spleen cell cultures with propanil for up to 8 h before T-cell activation resulted in reduced IL-6 but not IL-2 or IFN- production. These data indicate that propanil can selectively inhibit spleen cell cytokine production, which could contribute to the immunomodulatory effects previously described.
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