Serum Thyrotropin Response to Combined Arginine and Thyrotropin-Releasing Hormone Administration Provides Evidence for an Altered Somatostatinergic Tone in Acromegaly
作者:
Bartolomeo Merola,
Annamaria Colao,
Mauro Cataldi,
Emanuela Rossi,
Salvatore Longobardi,
Enzo Caruso,
Gaetano Lombardi,
期刊:
Hormone Research in Paediatrics
(Karger Available online 1992)
卷期:
Volume 37,
issue 1-2
页码: 7-13
ISSN:1663-2818
年代: 1992
DOI:10.1159/000182273
出版商: S. Karger AG
关键词: Growth hormone;Prolactin;Thyrotropin;Thyrotropin-releasing hormone test;Oral glucose tolerance test
数据来源: Karger
摘要:
The aim of this study was to evaluate plasma thyrotropin (TSH), prolactin (PRL) and growth hormone (GH) responses to the TSH-releasing hormone (TRH) test and to a combined arginine-TRH test (ATT-TRH) in 10 normal subjects and in 15 acromegalic patients. In controls, TSH responsiveness to TRH was enhanced by ATT (p < 0.001). When considering the 15 acromegalic patients as a whole, no significant difference in TSH responses was detected during the two tests. However, patients without suppression of plasma GH levels after oral glucose load showed an increased TSH responsiveness to the ATT-TRH test if compared to TRH alone (p < 0.025), while patients with partial suppression of plasma GH levels after glucose ingestion showed a decreased TSH responsiveness to ATT-TRH (p < 0.05). No difference was recorded in PRL and GH responses, evaluated as area under the curve, during TRH or ATT-TRH tests in controls and in acromegalics. In conclusion, (1) normal subjects have an enhanced TSH response to the ATT-TRH test and (2) acromegalic patients without suppression of GH levels after oral glucose load show a TSH responsiveness to the ATT-TRH test similar to that of controls, while acromegalics with partial GH suppression after oral glucose load have a decreased TSH responsiveness to the ATT-TRH test. These data suggest that acromegaly is a heterogeneous disease as far as the somatostatinergic tone is concerned.
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