Adult T-Cell Leukemia/Lymphoma in Northeastern Brazil: A Clinical, Histopathologic, and Molecular Study
作者:
Helenemarie Barbosa,
Achiléa Bittencourt,
Iguaracyra Barreto de Araújo,
Carlos Filho,
Roberto Furlan,
Célia Pedrosa,
Gildete Lessa,
William Harrington,
Bernardo Castro,
期刊:
JAIDS Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1999)
卷期:
Volume 21,
issue 1
页码: 65-71
ISSN:1525-4135
年代: 1999
出版商: OVID
关键词: HTLV-I-positive lymphoma;Adult T-cell leukemia/lymphoma;Pleomorphic lymphoma
数据来源: OVID
摘要:
The state of Bahia in the northeastern coast of Brazil is a region in which HTLV-I infection is endemic. This study investigated the characteristics of 28 HTLV-I-associated lymphomas/leukemias in this region. HTLV-I-infection diagnosis was based on serologic study, Southern blot analysis, and polymerase chain reaction (PCR) in neoplastic tissue. The main clinical differences between these lymphomas and adult T-cell leukemia (ATL) cases from other endemic areas were as follows. The mean age was 47 years; 20% of the cases occurred in young adults; and a predominance was found among male subjects (2:1), blacks, and of those of mixed race (96%). Histologically, 20 cases were T-cell pleomorphic leukemia/lymphoma, 5 wereMycosis fungoides-like cutaneous lymphoma, and 3 were CD30+large-cell anaplastic lymphoma. Immunohistochemistry demonstrated 4 cases of CD8+lymphoma. Proviral genomic sequences were demonstrated by PCR in 9 lymph node biopsy specimens and in 3 skin biopsy specimens. Southern blot was performed and was positive in 8 cases.
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