Attenuation of the ethanol‐induced hepatic redox change after chronic alcohol consumption in baboons: Metabolic consequencesin vivoandin vitro
作者:
Mikko P. Salaspuro,
Spencer Shaw,
Elizabeth Jayatilleke,
William A. Ross,
Charles S. Lieber,
期刊:
Hepatology
(WILEY Available online 1981)
卷期:
Volume 1,
issue 1
页码: 33-38
ISSN:0270-9139
年代: 1981
DOI:10.1002/hep.1840010106
出版商: W.B. Saunders
数据来源: WILEY
摘要:
AbstractAcute ethanol administration results in increased hepatic NADH/NAD+ratio and inhibition of galactose elimination, tricarboxylic acid cycle activity, and fatty acid oxidation. To determine how this redox change is affected by chronic alcohol consumption and to assess the resulting metabolic consequences, we studied baboons which were fed alcohol as 50% of their total calories. Redox changes were evaluated through measurement of galactose eliminationin vivoand lactate/pyruvate ratios in liver slicesin vitro. The metabolic consequences of these changes were assessed through measurement of CO2production and fatty acid oxidation in liver slices and hepatic lipid accumulation. Chronic alcohol feeding resulted in attenuation of inhibition of galactose elimination, increase in the lactate/pyruvate ratio, and decrease in fatty acid oxidation which were caused by acute ethanol administration. These metabolic adaptations were associated with reduced accumulation of hepatic fat.
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