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The Synthesis of 2′-Deoxyguanosines Having an Arylamino Group At the C-8 Position

 

作者: Chin-Yi Huang,   Francis Johnson,  

 

期刊: Natural Product Letters  （Taylor Available online 1992）
卷期: Volume 1, issue 1  

页码: 3-7

 

ISSN:1057-5634

 

年代: 1992

 

DOI:10.1080/10575639208048877

 

出版商: Taylor & Francis Group

 

关键词: aminofluorene;carcinogenic amines;ultimate carcinogens;nitrenium ion;2′-deoxy-8-(arylamino)guanosine;synthesis

 

数据来源: Taylor

 

摘要:

A general route is described for the synthesis of 8-arylamino derivatives of 2′-deoxyguanosine. the method takes advantage of (a) the far greater stability of the ribonucleoside series to acid conditions during the introduction of the aminoaryl group and (b) a modified form of Barton's radical deoxygenation procedure to remove the 2′-hydroxyl group. the synthetic pathway allows the preparation of the desired materials on a gram scale and avoids the use of an ultimate carcinogen as an intermediate.

 

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