Abstract:Antibody to hepatitis C has been variously detected in 1‐20% of haemodialysis patients in recent studies from overseas. To determine the frequency of antibodies to the C100‐3 protein of the hepatitis C virus (anti‐HCV) a cross‐sectional study was performed in 60 patients on maintenance haemodialysis in Western Sydney. Six patients (10%) were anti‐HCV seropositive. Four of the six anti‐HCV positive patients were also hepatitis B core antibody positive, compared with nine of 54 anti‐HCV negative patients (p<0.05). All anti‐HCV positive patients had received multiple blood transfusions. Serum alanine aminotransferase (ALT) was not useful as a screening test. Recent evidence suggests that anti‐HCV seropositivity underesti