Corneal thickness changes following sleep and overnight contact lens wear in the primate (Macaca fascicularis)
作者:
MadiganM. C.,
GillardS.,
KielyP. M.,
CrewtherD. P.,
BrennanN. A.,
EfronN.,
HoldenB. A.,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 6
页码: 809-815
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709034848
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Corneal thickness was monitored on seven cynomolgus monkeys (Macaca fascicularis) over a 76 hour period. During this time, corneal thickness measurements were also made on six monkeys after overnight wear of a hydrogel contact lens in one eye. Mean corneal thickness was 417±12um. An overall diurnal variation of 16±5um (3.8±1.2%) was found. During the first half hour after waking, corneal thickness changes ranged from -9um to +14um. After overnight contact lens wear, the cornea had swelled an average of 42±24um (9.1±4.8%). Following lens removal, the cornea returned to normal thickness within approximately 90 minutes. These results are similar to those found in humans and indicate that with respect to contact lens induced corneal thickness changes, the cynomolgus monkey is a suitable model for the physiological response to contact lens wear.
点击下载:
PDF (445KB)
返 回