The association between HLA B5 and ocular involvement in Behçet's disease in southern Turkey
作者:
Merih Soylu,
T. Reha Ersöz,
Eren Erken,
期刊:
Acta Ophthalmologica
(WILEY Available online 1992)
卷期:
Volume 70,
issue 6
页码: 786-789
ISSN:1755-375X
年代: 1992
DOI:10.1111/j.1755-3768.1992.tb04888.x
出版商: Blackwell Publishing Ltd
关键词: Behçet's disease;HLA B5;ocular involvement;visual prognosis
数据来源: WILEY
摘要:
AbstractHLA B5 plays an important role in the aetiology of Behçet's disease. The frequency of HLA B5 differs between racial groups and geographical regions. Ocular involvement, which could lead to serious complications, is a very important feature of Behçet's disease. Various racial groups having different genetic properties live in the Čukurova region, located in southern Turkey. To investigate the role of HLA B5 in Behçet's disease in Čukurova region, HLA B5 antigens were investigated by lymphocytotoxicity assay in 65 patients and 200 healthy controls. A significantly higher frequency was found in the patient group. Neither ocular involvement, nor the type of uveitis showed any correlation with HLA B5, but it was found that patients presenting with frequent ocular attacks had significantly higher HLA B5 positivity than the patients with rare attacks. This observation suggests that HLA B5 would be a negative factor in visual prognosis in Behçet's di
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