A 13‐year‐old femalewith varying degrees of vertical bone loss at the mesial surfaces of three first molars was treated by plaque control instruction, root planing and curettage of all sites and autologous tooth transplant into an extraction site, an autogenous iliac marrow graft at the second site, and passive eruption and osteoplasty at the third site. Two siblings had evidence of juvenile periodontitis and the mother had isolated bone defects involving some molars. Radiographic records were obtained of one of the male siblings at age 9 years and 10 months and 7 years and 10 months later, as well as of the mother. The male sibling had no evidence of bone loss at 9 years and 8 months, but advanced lesions were present at age 17 years and 8 months. Patterns of bone loss and teeth and tooth surfaces affected were different among the three family members studied. After 5 years, the three treated sites had normal sulcular depths. Bone regeneration was prominent at the marrow transplant site and tooth transplant site. Treatment was successful from a regenerative and stability point of view over a 5‐year period.