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Active microglia, sick astroglia and Alzheimer type dementias

 

作者: Manuel Nieto-Sampedro,   Francisco Mora,  

 

期刊: NeuroReport  （OVID Available online 1994）
卷期: Volume 5, issue 4  

页码: 375-380

 

ISSN:0959-4965

 

年代: 1994

 

出版商: OVID

 

关键词: Microglia;Astroglia;Alzheimer's disease;Amyloid;Calcium;Tau protein;Apolipoprotein E;Axonal transport;Neurodegeneration;Glutamate;IL-1

 

数据来源: OVID

 

摘要:

We propose that Alzheimer's disease is initiated by failure of axonal transport. After the neurodegeneration cascade is initiated, microglial and astroglial cells have major roles in directly and indirectly promoting self-sustaining neurodegeneration cycles. This hypothesis makes testable predictions and suggests logical therapies.

 

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