Mutagenicity studies on herring gulls from different locations on the great lakes. II. Mutagenic evaluation of extracts of herring‐gull eggs in a battery ofin vitromammalian and microbial tests
作者:
JenniferA. Ellenton,
MarciaF. McPherson,
K. Laurie Maus,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1983)
卷期:
Volume 12,
issue 2-3
页码: 325-336
ISSN:0098-4108
年代: 1983
DOI:10.1080/15287398309530430
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Herring‐gull (Larus argentatus) eggs were collected from five locations on the Great Lakes and from one colony on the Atlantic coast for organochlorine analysis and mutagenesis testing. The Great Lakes colonies were chosen for their different contaminant levels, while the Atlantic coast colony was used as a relatively clean control. The eggs were homogenized and extracted, and the extracts were tested in the Salmonella/mammalian microsome assay for induction of point mutations and in Chinese hamster ovary (CHO) cells for the Induction of sister chromatid exchanges (SCEs) and chromosome aberrations. None of the extracts was mutagenic inSalmonella, either in the presence or absence of metabolic activation. However, all of the extracts, including the clean control, caused significant increases in both the SCE rate and in the number of chromosome aberrations in the CHO cells. There was no apparent relationship between contaminant levels and the magnitude of these responses or the doses at which they occurred, although the chemical analysis indicated a wide range in the concentrations of the different organochlorides present.
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