Na+-H+exchange and other ion-transport systems in erythrocytes of essential hypertensives and spontaneously hypertensive rats: a comparative analysis
作者:
Sergei Orlov,
llya Postnov,
Nikolai Pokudin,
Vladimir Kukharenko,
Yuvenali Postnov,
期刊:
Journal of Hypertension
(OVID Available online 1989)
卷期:
Volume 7,
issue 10
页码: 781-788
ISSN:0263-6352
年代: 1989
出版商: OVID
关键词: Na+-H+and Na+-Li+countertransport;Na+,K+cotransport;Ca2+-activated K+channels;[Ca2+]1-induced haemolysis;primary hypertension
数据来源: OVID
摘要:
The activity of ion-transport systems and Ca2+-induced erythrocyte haemolysis were compared between patients with essential hypertension and two strains of spontaneously hypertensive rats. Previous data on the increased rate of Na+-Li+countertransport in erythrocytes of essential hypertensives were confirmed in this study. However, identification of Na+-Li+countertransport in rat erythrocytes remained a complicated problem because of the high rate of sodium-independent efflux of Li+. The rate of Na+-H+exchange increased by 50-80% both in spontaneously hypertensive Wistar-Kyoto rats (SHR) and in patients with essential hypertension. No difference between Milan hypertensive strain rats (MHS) and Milan normotensive strain rats (MNS) was found.The rate of Na+,K+cotransport increased in SHR and MHS erythrocytes compared with rats of the control strains [normotensive Wistar-Kyoto rats (WKY) and MNS; 30-50 and 90-110%, respectively]. No difference in this parameter was found between patients with essential hypertension and healthy subjects. Erythrocytes of patients with essential hypertension and of SHR were characterized by a higher sensitivity of their K+channels to the increased concentration of intracellular Ca2+. This parameter did not change in MHS erythrocytes. Ca2+-induced haemolysis increased four- to fivefold in MHS erythrocytes compared with MNS and did not change in erythrocytes of SHR and patients with essential hypertension.The conclusion from these data is that the SHR strain is a more adequate model of human essential hypertension than the MHS.
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