Acute‐phase reactant proteins and antioxidants in rats intoxicated chronically with paraquat
作者:
Kayoko Minakata,
Osamu Suzuki,
Sachiko Oh‐ishi,
Izumi Hayashi,
Shin‐ichi Saito,
Naoko Harada,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1995)
卷期:
Volume 44,
issue 1
页码: 29-41
ISSN:0098-4108
年代: 1995
DOI:10.1080/15287399509531941
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Paraquat dichloride at 250 ppm in the diet was fed continuously to rats. Though no apparent effect of paraquat was observed until 10 d, some rats then began to show several symptoms such as diarrhea, anorexia, epistaxis, and hypokinesia, and in some cases rats died after this period. The biochemical examination of plasma components revealed appreciable changes in the concentrations of an acute‐phase reactant protein and some vitamins that act as antioxidants. α‐Cysteine proteinase inhibitor increased by 5‐fold, and vitamin C and its radical increased by 1.5‐ and 1.7‐fold, respectively, whereas α1 proteinase inhibitor decreased slightly. Paraquat enhanced the cysteine proteinase inhibitor levels in lung, liver, and kidney by 6.2‐, 6.0‐, and 4.5‐fold of control, respectively. Among three components of α‐cysteine proteinase inhibitor, the T kininogen level of treated rat plasma was about eight‐fold higher than control, whereas the high‐molecular‐weight kininogen level was unchanged. The large increment of T kininogen was also seen in lungs of the treated rats.
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