Classical Kaposi’s Sarcoma in Caucasians in Africa – Experience at the Johannesburg Hospital (1978–1992)
作者:
M.E. Stein,
A. Kantor,
D. Spencer,
W.R. Bezwoda,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 3
页码: 182-187
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247135
出版商: S. Karger AG
关键词: Kaposi’s sarcoma;classical form;South Africa;Retrospective study;Second malignancies
数据来源: Karger
摘要:
The data are scant concerning classical Kaposi’s sarcoma (CKS) among the Caucasian population of Africa. A description of the clinical features of 15 such patients, treated and followed up at the Johannesburg General Hospital over a 14-year period (1978–1992) is presented. All patients were negative for the human immunodeficiency virus. After a mean follow-up of 50 months (range: 7–168 months), 2 patients are alive with absent or minimal disease; 1 patient is alive with stable disease and 1 has active disease involving his extremities. Three patients were lost to follow-up but had minimal or no disease when last seen. Five patients died of unrelated causes but also had minimal or no disease at their last visit. One patient died of sepsis related to active KS. Only two patients died of progressive KS. No alterations in humoral or cellular immunity were demonstrated in 2 patients with persistent disease. Four (27%) patients developed lymphoproliferative disorders including non-Hodgkin’s lymphoma, Walden-ström’s macroglobulinemia, Hodgkin’s disease and Castleman’s disease (angio-follicular lymph node hyperplasia) preceding or following the diagnosis of CKS. These data confirm the indolent nature and good outcome of the classical form of Kaposi’s sarcoma among Caucasians in the southern African region. The marked association between CKS and lymphoproliferative disorders warrants a long-term awareness and continued monitoring for the
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