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Comparison of Silylation Reaction Rates of Different Reagents : Catalytic Effect of Methoxyamine on the Silylation of Sterically Hindered Hydroxyl Groups

 

作者: AndrásB. Benkö,   Veronika Mann,  

 

期刊: Analytical Letters  （Taylor Available online 1980）
卷期: Volume 13, issue 9  

页码: 735-739

 

ISSN:0003-2719

 

年代: 1980

 

DOI:10.1080/00032718008077994

 

出版商: Taylor & Francis Group

 

关键词: steroid derivatisation;gas-chromatography;trimethyl-silyl ethers;catalysis

 

数据来源: Taylor

 

摘要:

A comparison of different silylating agents was conducted by gas-chromatography, using methandienon e(17α-methyl-androsta-1, 4-dien-17β-ol-3-one) as a model substance for steroids with hindered hydroxyl groups. A very significant catalytic effect of methoxy-amine on the reactions was found with all examined silylating agents. A 100% yield was found using N-trimethylsilyl-imidazole in combination with the catalyst in an “on-column” reaction.

 

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