RENAL TRANSPLANT PATIENTS MONITORED BY THE CELL‐MEDIATED LYMPHOLYSIS ASSAY
作者:
ELS GOULMY,
THEO STUNEN,
ALBERT GROENEWOUD,
GUIDO PERSIJN,
ELS BLOKLAND,
Jos POOL,
LEEN PAUL,
JON VAN ROOD,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 4
页码: 559-559
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
Donor-specific cytotoxic T cell activity was measured over a period of 5 years after transplantation using the cell-mediated lympholysis (CML) test in 124 recipients of unrelated kidney allografts who received conventional immunosuppressive therapy consisting of azathioprine and prednisone. Since patients with a functioning transplant frequently display donor-specific CML nonresponsiveness in vitro, we addressed the question of whether the CML status has a predictive value regarding the graft prognosis at any time interval until 5 years posttransplantation. From log-rank type analyses we conclude that the estimated relative risk calculated over the whole follow-up period of a CML-responder in the category of transplant rejectors is 1.25 with 95% confidence bounds between 0.94 and 1.65. Measurements of CML responder status during follow-up seem to have only limited prognostic value, although the relative risk is borderline significant when the analysis is restricted to the period between 2 weeks and 6 months posttransplantation.
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