A Case of Lipoprotein Glomerulopathy Successfully Treated with Probucol
作者:
Masaki Amenomori,
Masakazu Haneda,
Junichirou Morikawa,
Itsurou Nishigaki,
Shiro Maeda,
Hideki Hidaka,
Ryuichi Kikkawa,
Yukio Shigeta,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 1
页码: 109-113
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187897
出版商: S. Karger AG
关键词: Lipoprotein glomerulopathy;Hyperlipoproteinemia;Immunoglobulin A nephropathy;Probucol
数据来源: Karger
摘要:
A 54-year-old woman presented proteinuria and severe hyperlipoproteinemia, She had type III hyperlipoproteinemia with the phenotype E2/2. Renal biopsy specimen revealed lipoprotein thrombi within the glomerular capillary lumina without tubulointerstitial lesion and deposition of IgA in the mesangium and peripheral capillary loops, indicating lipoprotein glomerulopathy with IgA nephropathy. Treatment with probucol resulted in the improvement of both hyperlipoproteinemia and proteinuria with the disappearance of the lipoprotein thrombi in the glomerular capillary without any change in the mesangial IgA deposition. The data suggest that probucol may be effective against the early stage of lipoprotein glomerulopathy with less lipoprotein thrombi and without tubulointerstitial damage.
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