This study examined the possible relationship between Karasek’s job strain model and blood coagulation factors VII and VIII as risk factors for cardiovascular disease in Korean male workers. Based on the postulation of the model, we invited 160 male workers (40 people each subgroup) using a stratified sampling from the base population (n = 1071). In univariate analyses, decision latitude was negatively related to blood coagulation factors VII and VIII. Work demand was positively related to coagulation factor VIII, but not to factor VII. Hierarchical multiple regression analyses showed that job strain was associated with blood coagulation factor VIII after controlling for smoking, blood pressure, total cholesterol, and HDL cholesterol. These results indicate that job characteristics may be related to blood coagulation, and contribute to the development of cardiovascular disease with other classical risk factors.