The influence of glucose, given orally and intravenously, on the acceleration of plasma clotting and appearance of lipemia following the feeding of peanut oil was determined in dogs. Oral glucose blocked or masked the appearance of plasma lactescence and clotting accelerator activity, whereas intravenous administration tended to delay their appearance. In other experiments heparin abolished or reduced plasma lactescence without modifying clotting accelerator activity induced by fat feeding.