We have prepared by electrodepositionNi80Fe20/Cumultilayered nanowires into the pores of polymer membranes and performed giant magnetoresistance (GMR) measurements in the current perpendicular to the layer planes geometry. GMR ratios as high as 80&percent; have been obtained at 4.2 K. Two types of structure have been studied: conventionalNi80Fe20/Cumultilayers and multilayers composed ofNi80Fe20/Cu/Ni80Fe20trilayers magnetically isolated by long Cu rods. ©1997 American Institute of Physics.