Possible Basis for Primary Prevention of Birth Defects with Folic Acid
作者:
T.K.A.B. Eskes,
期刊:
Fetal Diagnosis and Therapy
(Karger Available online 1994)
卷期:
Volume 9,
issue 3
页码: 149-154
ISSN:1015-3837
年代: 1994
DOI:10.1159/000263923
出版商: S. Karger AG
关键词: Birth defects;Folic acid;Homocysteine;Neural tube defects;Recurrent miscarriage;Placental infarcts
数据来源: Karger
摘要:
Prepregnancy counselling is efficient in cases of chronic maternal disease, selection of medication and avoiding bad life habits. A new policy is the use of folic acid in the periconceptional period for the purpose of reducing the chance of having a baby with neural tube defects (NTD). Research in progress at the Department of Obstetrics and Gynaecology in Nijmegen, the Netherlands, is presented demonstrating that a derangement of methionine-homocysteine metabolism could be the underlying mechanism of pathogenesis and prevention with folic acid. Such derangement was found in ± 20% of cases with NTD, recurrent miscarriage and placental infarcts (abruption) and offers new possibilities for primary prevention in three major areas
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