Aberrant Appearance of Lung Surfactant Protein A in Sera of Patients with Idiopathic Pulmonary Fibrosis and Its Clinical Significance
作者:
Yasuhito Honda,
Yoshio Kuroki,
Noriharu Shijubo,
Takuya Fujishima,
Hiroki Takahashi,
Kenji Hosoda,
Toyoaki Akino,
Shosaku Abe,
期刊:
Respiration
(Karger Available online 1995)
卷期:
Volume 62,
issue 2
页码: 64-69
ISSN:0025-7931
年代: 1995
DOI:10.1159/000196393
出版商: S. Karger AG
关键词: Pulmonary surfactant;Surfactant protein;A Idiopathic pulmonary fibrosis;Pulmonary alveolar proteinosis;Serum lactate dehydrogenase
数据来源: Karger
摘要:
Pulmonary surfactant protein A (SP-A) is known to be a major phospholipid-associated glycoprotein in pulmonary surfactant, which is specific to the lung. In this study, the SP-A concentrations in sera of patients with various lung diseases were determined using an enzyme-linked immunosorbent assay. Patients with idiopathic pulmonary fibrosis (IPF) and pulmonary alveolar proteinosis (PAP) exhibited prominently high concentrations of serum SP-A compared to those of other lung diseases and healthy volunteers, although there were significant increases in serum SP-A concentrations in patients with pulmonary tuberculosis, chronic pulmonary emphysema, diffuse panbronchiolitis and bacterial pneumonia compared to those of healthy volunteers. Successive measurement in 2 patients with IPF showed that serum SP-A levels reflect the disease activity of IPF. In patients with IPF, serum SP-A concentrations were significantly correlated with those of serum lactate dehydrogenase, whereas there were no significant correlations of serum SP-A concentrations with erythrocyte sedimentation rate, arterial oxygen saturation, vital capacity and carbon monoxide diffusing capacity. Determination of serum SP-A will contribute to diagnosing IPF and PAP, and may reflect the disease activity of IPF.
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