Vascular binding sites and biological activity of vasopressin in DOCA-salt hypertensive rats
作者:
Richard Larivière,
Jean St-Louis,
Ernesto Schiffrin,
期刊:
Journal of Hypertension
(OVID Available online 1988)
卷期:
Volume 6,
issue 3
页码: 211-217
ISSN:0263-6352
年代: 1988
出版商: OVID
关键词: Vasopressin receptor regulation;blood vessel reactivity;plasma vasopressin concentrations;mineralocorticoid hypertension
数据来源: OVID
摘要:
In order to understand the regulation of vascular vasopressin receptors in hypertension, vasopressin (AVP) binding sites and the pressor response to AVP in the perfused mesenteric vasculature of DOCA-salt hypertensive rats, sodium-loaded and DOCAtreated rats were investigated. The binding capacity for AVP (Bmax) was significantly reduced (P< 0.05) in uninephrectomized, DOCA-treated rats (70 ± 17fmol/mg protein) and in DOCA-salt hypertensive rats (90 ± 9 fmol/mg protein) with respect to uninephrectomized rats (130 ± 32 fmol/mg protein) or uninephrectomized salt-loaded rats (155 ± 47 fmol/mg protein), with no change in affinity. In these rats with lower receptor density, however, the maximal pressor response to AVP in the perfused mesenteric vascular bed was increased (P< 0.05). In DOCA-salt hypertensive rats plasma AVP was higher than in the other groups. In similarly treated rats with intact kidneys, which therefore did not become hypertensive, receptor density was significantly decreased after combined DOCA-salt treatment, together with an exaggerated pressor response to AVP and increased plasma AVP concentrations. These results suggest that AVP receptors are down-regulated when there is an increment in the plasma concentration of AVP, although other factors may also play a role. Biological responses to AVP are, however, increased in spite of decreased receptor density and this phenomenon is independent of the elevation in blood pressure and results from an exaggerated response mediated by post-receptor mechanisms
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