首页   按字顺浏览 期刊浏览 卷期浏览 Regulation of Mouse Brain Tryptophan Hydroxylase Activity
Regulation of Mouse Brain Tryptophan Hydroxylase Activity

 

作者: T.M. Cho,   H.H. Loh,  

 

期刊: Pharmacology  （Karger Available online 1973）
卷期: Volume 10, issue 4  

页码: 215-219

 

ISSN:0031-7012

 

年代: 1973

 

DOI:10.1159/000136441

 

出版商: S. Karger AG

 

关键词: End-product inhibition;5-Hydroxyindoleacetic acid;Serotonin;Tryptophan hydroxylase

 

数据来源: Karger

 

摘要:

By using drugs which alter the levels ofserotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE), we have shown that they effecttryptophan hydroxylase activity in the CNS. Relatively high doses of 5-HIAA and NE added in vitro also inhibittryptophan hydroxylase. The possibility that brain serotonin biosynthesis is regulated via an end-product feedback control mechanism is discussed.

 

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