Autologous Immune Complex Nephritis in Streptozotocin-Induced Diabetic Rats
作者:
Seiya Okuda,
Yukinori Oh,
Kaoru Onoyama,
Satoru Fujimi,
Teruo Omae,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 37,
issue 3
页码: 166-173
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183238
出版商: S. Karger AG
关键词: Streptozotocin-induced diabetic rat;Immune complex nephritis;Heymann nephritis;Diabetes mellitus
数据来源: Karger
摘要:
In order to investigate the influence of diabetes mellitus on immune complex-mediated nephritis, we produced Heymann nephritis in streptozotocin-induced diabetic rats (DM-HN group) in which the clinical course for 24 weeks and histological changes were examined. Nondiabetic rats with Heymann nephritis (HN group) and diabetic rats (DM group) were also examined as controls. The degree of proteinuria, hypoproteinemia, hyperlipidemia and anemia were more pronounced and the mortality rate was higher in the DM-HN group than in the HN group or in the DM group. Histologically, larger and more subepithelial or intramembranous electron-dense deposits as well as a more markedly thickened glomerular basement membrane (GBM) were observed in the DM-HN group than in the HN group. In conclusion, the nephrotic manifestations and histological changes in the GBM in Heymann nephritis were augmented by the association with diabetes mellitus.
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