Variation of Collagenous and Non-Collagenous Proteins of Human Knee Joint Menisci with Age and Degeneration
作者:
A.M. Ingman,
P. Ghosh,
T.K.F. Taylor,
期刊:
Gerontology
(Karger Available online 1974)
卷期:
Volume 20,
issue 4
页码: 212-223
ISSN:0304-324X
年代: 1974
DOI:10.1159/000212017
出版商: S. Karger AG
关键词: Meniscus;Collagen;Non-collagen proteins;Degeneration
数据来源: Karger
摘要:
The chemical composition has been determined in inner, middle and peripheral zones of 50 human knee joint menisci of ages 0–86 years. Of these, 12 showed areas of degeneration which were analysed separately. On a dry weight basis, normal adult tissues contained 77.9 ± 0.4% collagen, 8.1 ± 0.8% non-collagenous proteins (NCP) and 1.0 ± 0.1 % hexosamine. With aging, the level of collagen increases and NCP declines. In degenerate areas, a statistically significant loss in collagen, and rise in NCP and hexosamines was observed, relative to normal menisci of the same
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