Liver Microsomal Mixed-Function Oxidases in Response to Polyunsaturated/Saturated and n-6/n-3 Fatty Acid Ratios of Dietary Lipids in Rats
作者:
Morio Saito,
Michio Yamaguchi,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1994)
卷期:
Volume 38,
issue 1
页码: 28-39
ISSN:0250-6807
年代: 1994
DOI:10.1159/000177791
出版商: S. Karger AG
关键词: Dietary lipids;Polyunsaturated/saturated fatty acid ratio;n-6/n-3 fatty acid ratio;Mixed-function oxidases;Cytochrome P-450;Phenobarbital induction;Microsomal fatty acid composition
数据来源: Karger
摘要:
The effects of various polyunsaturated/saturated (P/S; 0.29-2.74) and n-6/n-3 (0.49-11.21) ratios of dietary fatty acids and of phenobarbital (PB) stimulation on the activity of liver microsomal mixed-function oxidase (MFO) system were studied in rats using a combination of palm oil, safflower oil and fish oil concentrate. When the n-6/n-3 ratio was kept constant (4.6-4.9) without induction by PB, the highest P/S ratio (2.74) tended to increase the basal PB-uninduced MFO activities; while the PB-induced MFO activities were elevated as the dietary P/S ratio increased. This definitely indicates the role of both n-6 and n-3 polyunsaturated fatty acids (PUFAs) in the elevation of MFO activities with and without PB stimulation. Whereas the n-6/n-3 ratio was varied while maintaining a constant P/S ratio (1.3), the PB-induced MFO activities were significantly elevated by decreasing the n-6/n-3 ratio although the MFO activities were not affected without PB stimulation. The MFO activities induced by PB were directly related to the n-3 PUFA content and inversely related to the n-6 PUFA content of the diets with n-6/n-3 ratios less than 4.55. These results obtained herein suggest that there are significant differences in the effects of n-6 and n-3 PUFAs on liver microsomal MFO activities, especially in relation to the induction of MFOs by PB.
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