Studies on the estrogenic activity of a coffee extract
作者:
D. D. Kitts,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1987)
卷期:
Volume 20,
issue 1-2
页码: 37-49
ISSN:0098-4108
年代: 1987
DOI:10.1080/15287398709530960
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Ethyl ether extracts derived from coffee were tested for in vitro estrogenic and in vivo uterotropic activities. Coffee extracts, unlike tea and cocoa, were found to actively compete with 17ß‐estradiol for uterine cytosol binding sites. The biologically active fractions possessed an unique ultraviolet absorbance spectrum that excluded them from containing flavonoid, coumestan, or resorcyclic acid lactone constituents. Coffee extracts administered to immature female mice for 3 d in feeding studies displayed significant (p < 0.05) uterotropic responses, which were similar to results obtained in mice treated with a standard 17ß‐estradiol dose. Additional studies in mice disclosed that coffee extracts did not reduce the uterotropic effect normally induced by 17ß‐estradiol when administered simultaneously with estradiol. The complete estrogenic effects of coffee constituents, coupled with their failure to inhibit a biological response evoked by estradiol, strongly suggest that coffee contains constituent(s) that are weakly estrogenic.
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