J10 lactate‐induced polycythemia in newts
作者:
Giuliano Frangioni,
Gianfranco Borgioli,
期刊:
Journal of Experimental Zoology
(WILEY Available online 1983)
卷期:
Volume 225,
issue 1
页码: 1-4
ISSN:0022-104X
年代: 1983
DOI:10.1002/jez.1402250102
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractSpecimens ofTriturus cristatus carnifex(Laurenti) raised for about 3 weeks in a 3 gm/liter solution of sodium lactate present a slight alkalosis and a mean increase of about 35% in the red blood cell count in comparison to control animals raised in identically oxygenated water; analogous treatment with an equal molar concentration of sodium pyruvate produces only alkalosis. Since lactate alone determines an increase in the number of erythrocytes as does hypoxia, and hypoxia always induces an increase in plasma lactate levels, it can be deduced that erythropoietin (ESF) production is stimulated by an increase in plasma lactate and not directly by a lack of oxygen. The hypothesis that ESF in newts is produced by the “lactate‐sensitive cells” of the renal corpuscles, which hypertrophy after experimental anaemia or treatment with lactic acid salts, is indirectly conf
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