Diet and Cardiac Arrhythmia: Effects of Lipids on Age-Related Changes in Myocardial Function in the Rat
作者:
J.S. Charnock,
P.L. McLennan,
M.Y. Abeywardena,
W.F. Dryden,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1985)
卷期:
Volume 29,
issue 5
页码: 306-318
ISSN:0250-6807
年代: 1985
DOI:10.1159/000176986
出版商: S. Karger AG
关键词: Age-related changes;Ca++;Catecholamine stress;Dietary lipids;Dysrhythmia;Myocardial function;Rats
数据来源: Karger
摘要:
Male rats were fed for 3–4 months (short-term) or 12–15 months (long-term) on a standard laboratory diet alone (control) or supplemented with sunflower seed oil (SSO, 12 % w/w) or sheep kidney fat (SKF, 12% w/w). Papillary muscles were electrically driven (1 Hz, 5 ms, supramaximal voltage) at 37 °C in Krebs-Henseleit solution, and contractions were measured isometrically. Both the positive inotropic responses to CA++ and the incidence of spontaneous tachyarrhythmias under catecholamine stress were increased by short-term SKF feeding and with age in control and SKF groups, whereas SSO prevented these changes. The results show a marked effect of age upon ventricular myocardial function in the rat, which appears to be accelerated by the consumption of animal (saturated) fat while polyunsaturated vegetable oil provides some degree of protection. It is suggested that changes in membrane lipid composition can alter the Ca++ handling characteristics of myocardial c
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