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The Dilemma of Occupational RhinitisManagement Options

 

作者: Johan Hellgren,   Göran Karlsson,   Kjell Torén,  

 

期刊: American Journal of Respiratory Medicine  (ADIS Available online 2003)
卷期: Volume 2, issue 4  

页码: 333-341

 

ISSN:1175-6365

 

年代: 2003

 

出版商: ADIS

 

关键词: Rhinitis, treatment;Antihistamines, therapeutic use;Quality of life;Corticosteroids, therapeutic use;Leukotriene antagonists, therapeutic use;Omalizumab, therapeutic use;Research and development;Monoclonal antibodies, therapeutic use;Montelukast, therapeu

 

数据来源: ADIS

 

摘要:

Occupational rhinitis is a common heterogeneous group of inflammatory conditions in the nose, caused by exposure to airborne irritants and sensitizers in the occupational environment. The mechanism can be allergic, neurogenic or toxic.Data from several epidemiologic studies indicate that animal dander, organic dusts, latex and chemicals can cause occupational rhinitis, but because of methodological problems as well as weaknesses in the definition of occupational rhinitis, occupational exposure is probably an underestimated cause of rhinitis. The effect of rhinitis on the mental aspects of quality of life and substantial costs due to loss of productivity make it important to diagnose and treat occupational rhinitis. Diagnosis relies on a history of exposure, skin prick testing and, if possible, nasal provoacation. Avoidance of exposure, protective measures at the workplace and medical treatment, with agents such as second generation antihistamines and nasal corticosteroids, can make it possible to avoid progress of the disease from rhinitis to asthma. The efficacies of montelukast, a leukotrienne receptor antagonist, and omalizumab, an anti-immunoglobulin E monoclonal antibody in the treatment of occupational rhinitis are yet to be evaluated

 

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