Sulfasalazine‐Induced Fulminant Hepatic Failure
作者:
G. Marinos,
J. Riley,
D. Painter,
G. McCaughan,
期刊:
Journal of Clinical Gastroenterology
(OVID Available online 1992)
卷期:
Volume 14,
issue 2
页码: 132-135
ISSN:0192-0790
年代: 1992
出版商: OVID
关键词: Sulfasalazine;Drug complications;Liver failure
数据来源: OVID
摘要:
We report two cases of massive hepatic necrosis associated with sulfasalazine. Both patients had underlying inflammatory bowel disease. One of the patients had a history of an ill-defined autoimmune disorder (Sjögren's syndrome). Symptoms and signs of a generalized hypersensitivity reaction were present in both patients. One patient died of a subarachnoid hemorrhage while awaiting transplant, the second died 2 weeks after transplant from disseminated aspergillosis. These two cases remind us of one of the potential hazards of sulfasalazine at a time when alternative therapies are now available.
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