Dose Responsive Effects of PDGF-BB, PDGF-AA, EGF, and bFGF on Granulation Tissue in a Guinea Pig Partial Thickness Skin Excision Model
作者:
LegrandEdmund K.,
KiorpesTimothy C.,
BurkeJohn F.,
CostaDonald E.,
期刊:
Growth Factors
(Taylor Available online 1993)
卷期:
Volume 8,
issue 4
页码: 307-314
ISSN:0897-7194
年代: 1993
DOI:10.3109/08977199308991575
出版商: Taylor&Francis
关键词: Wound healing;Guinea pig;Growth factor;PDGF;ECF;FGF
数据来源: Taylor
摘要:
A guinea pig partial thickness skin excistoti model wx used to evaluatc the effects of recombinant human PDGF-BB, 1′17GF-AA, ECF, and bFGF on granuLition tissue (neodermis) formation. These growth factors tended to increcisr the thickness of the granulation tissue bed when assesstd histcilogitally at day 7. Using only four animals per group, PDGF-BB at 30 and 100μg/ml consistently and significantly incwaseil the thickness of the granulation bed 2–3 limits that of control. Except for the increased thickness, the granulation tissue appmred normal. I'DGF-AA and EGF also significantly increased the granulation tissue thickness, and bFGF gave indications of an effect. Therc was no evidence of synergistic effects bthwxi PDGF-BB, EGF, and/or bFCF.
点击下载:
PDF (4053KB)
返 回