AbstractA case of a 66-year-old woman with clinical myxoedema and positive thyroid autoantibodies is reported. An unusual feature was the discrepancy between normal total and free T, and T. levels and high TSH values, in the absence of a pituitary adenoma. This clinical picture can be explained by a peripheral resistance to tlyroid hormone which led to hypothyroidism after the thyroiditis had sufficiently reduced the eland secretory reserve.