Subeschar Antibiotic Infusion in the Treatment of Burn Wound Infection
作者:
WILLIAM McMANUS,
ARTHUR MASON,
BASIL PRUITT,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1980)
卷期:
Volume 20,
issue 12
页码: 1021-1023
ISSN:0022-5282
年代: 1980
出版商: OVID
数据来源: OVID
摘要:
In a reproducible infected rat burn model, subeschar infusion of antibiotics failed to protect the animals from death via burn wound invasion excepting those animals receiving carbenicillin. Subcutaneous injection of maximal doses of carbenicillin at a distance from the burn wound protected these animals equally well. Some advantage was defined for the subeschar route of administration with suboptimal doses of carbenicillin.More important is the fact that prospective selection of an effective antibiotic could not be made on the basis of in vitro antibiotic sensitivity tests.
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