Effects of Electrical Stimulation of Brain
作者:
Robert H. Pudenz,
William F. Agnew,
Leo A. Bullara,
期刊:
Brain, Behavior and Evolution
(Karger Available online 1977)
卷期:
Volume 14,
issue 1-2
页码: 103-125
ISSN:0006-8977
年代: 1977
DOI:10.1159/000125578
出版商: S. Karger AG
关键词: Electrodes;Electrode arrays;Blood-brain barrier;Neural damage;Electrical stimulation of brain;Neural prostheses;Horseradish peroxidase;Ultrastructural damage
数据来源: Karger
摘要:
The use of implantable neural prostheses activated by radiofrequency transmission requires that the materials in the device and the stimulation techniques are not injurious to neural tissue, particularly the neurons. In this report, we discuss our experiences in the search for safe stimulation techniques. Acute and chronic experiments have been performed to evaluate electrode design and materials and to observe the effects of various stimulus protocols on the blood-brain barrier and brain. Neural tissue underlying the stimulated and control electrodes has been examined with both light and electron microscopy. Observations up to the present time indicate that the charge per phase is the most relevant stimulus parameter although the importance of charge density and current density cannot be underestimated.
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