AbstractThe particular problem addressed here is that of regulating the glucose concentration and possibly the insulin concentration in the blood of the human subject. The state equations which relate the concentrations of plasma glucose and insulin in the metabolic system are obtained. Consequently, the associated pulsed transfer function matrix is derived. An efficient algorithm incorporating a three-term (PID) controller is employed to regUlate the system at hand. It Rhould be emphasized that the required continuous measurement of the glucose concentration involves a long time delay that makes the problem qUite complicated. The presented r~alistic simulation results validate the regulation performance of the proposed algorithm.