Linkage Analyses of Multiple Endocrine Neoplasia, Type 2 (MEN-2) with 23 Classical Genetic Polymorphisms
作者:
Susan D. Kruger,
Joseph M. Gertner,
Robert S. Sparkes,
Lori E. Haedt,
Michol Crist,
Maryellen C. Sparkes,
Myron Genel,
Kenneth K. Kidd,
期刊:
Human Heredity
(Karger Available online 1986)
卷期:
Volume 36,
issue 1
页码: 6-11
ISSN:0001-5652
年代: 1986
DOI:10.1159/000153592
出版商: S. Karger AG
关键词: Multiple endocrine neoplasia type 2;Genetic linkage;Dominantly inherited cancer
数据来源: Karger
摘要:
Linkage analyses were performed in a single large family with multiple endocrine neoplasia, type 2 (MEN-2) between 23 classical genetic polymorphisms and MEN-2. We exclude close linkage of the locus for MEN-2 with ABO, ACPI, BF, ESD, Fy, GALT, GLO1, Jk, MNSs, P, PGM1, Rh and TF, as well as absolute linkage with GPT. These results raise to about 6% the proportion of the genome that has been excluded in this one family. Somewhat positive lod scores were obtained for GC (0.92 at Θ = 0), GPT (0.73 at Θ = 0.1) and HP (1.49 at Θ = 0.05); although not statistically significant, these findings suggest regions of the genome that warrant additional stu
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