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Enrichment of Dystrophy-Associated Antigen from Erythrocyte Membranes of Mice with Muscular Dystrophy

 

作者: AkindeleJohnson,   OresajoChristian,   PradhanSikta,   HeadingsVerle,  

 

期刊: Journal of Neurogenetics  （Taylor Available online 1986）
卷期: Volume 3, issue 1  

页码: 49-59

 

ISSN:0167-7063

 

年代: 1986

 

DOI:10.3109/01677068609106894

 

出版商: Taylor&Francis

 

关键词: mouse muscular dystrophy;dystrophy-associated antigen;erythrocyte membrane;immunoaffinity chromatography

 

数据来源: Taylor

 

摘要:

SummaryIn a previous report, it was shown that erythrocyte membranes from mice with muscular dystrophy of strain129/ReJ-dymanifest a unique antigen. In the current study, this antigen was enriched from solubilized membranes by a two-step solid phase immunoadsorbent. The enriched fraction retained antigenicity as well as a reduced set of electrophoretic forms of protein over that seen in solubilized membranes. The enriched fraction contained no novel molecular weight species but several were noticeably enriched, particularly at 54,000 daltons.

 

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